Academia.edu is a platform for academics to share research papers. DESCRIPTION. ARTHROTEC (diclofenac sodium/misoprostol) is a combination product containing diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E 1 analog. What is Misoprostol? Misoprostol, sold under the brandname Cytotec among others, is a medication used to start labor, cause an abortion, prevent and treat stomach ulcers, and treat postpartum bleeding due to poor contraction of the uterus. Misoprostol, sold under the brandname Cytotec among others, is a medication used to prevent and treat stomach ulcers, start labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. Methotrexate Methotrexate gives women the opportunity to have a termination performed as early as a week prior to missing their period up to 9 weeks from the last menstrual period. Methotrexate is not only used to stop the growth of pregnancy tissue, but it is used to treat different cancers (head and neck, breast, female genital tract. Methotrexate is another abortion-related medication possibly referred to as the abortion pill. In either of these inquiries, individuals asking about this medication are considering terminating their pregnancy. Here’s the deal: The “abortion pill” is the popular name for a safe and effective way to end an early pregnancy using a combination of two medicines: mifepristone and misoprostol. Misoprostol is labeled as an ulcer medication but has been found to be helpful in miscarriage management. Its use for management of missed or incomplete miscarriages is considered to be off-label by the Food and Drug Administration (FDA), but it has been well-studied and is widely recommended. Misoprostol is contraindicated during pregnancy for use to reduce the risk of stomach ulcers associated with NSAIDs (the FDA-approved indication).